Residents of the Charlotte Harbor area enjoy an unhurried, leisurely pace of life in a cherished spot internationally renowned as one of the world's top sport fishing destinations. Charlotte Harbor, Florida's second-largest open water estuary, is formed by the convergence of saltwater from the Gulf of Mexico with fresh water from the Peace and Myakka rivers. Opportunities for nautical recreation are endless, from tarpon fishing to kayaking to spending the day sailing amidst the nearby barrier islands. ... more.Waterfront homes in Charlotte Harbor are available in a range of prices. Home styles range from classic bungalows, modest ranches, and contemporary to luxurious estates. In addition, parcels of vacant land are available so you can build the waterfront home you want.